INDICATION Anti-thrombotic for chronic prevention of cardiovascular disease and cancer chemoprevention.
PRODUCT DESCRIPTION ATB-340 is a hydrogen sulfide-releasing derivative of low-dose aspirin. Low-dose aspirin is a widely prescribed anti-thrombotic for the maintenance of cardiovascular health.
TARGET SEGMENT(S) AND MARKETPLACE Low-dose aspirin is becoming increasingly regarded as a panacea for cardiovascular disease prevention, and emerging data now suggest it decreases the risk of multiple cancers. Aspirin is one of the most widely prescribed medications in the world, with its use in the United States greater than 50% in middle-age adults according to a recent national survey (American Journal of Preventative Medicine). However, aspirin, like other NSAIDs, can cause stomach ulcers and serious gastrointestinal bleeding in an appreciable portion of the population.
WEAKNESS OF PROTON PUMP INHIBITORS (“PPIs”)  Several combination therapies have been launched recently to address the GI safety issue by combining low-dose aspirin with a proton pump inhibitor (“PPI”). However, although PPIs reduce the risk of upper GI bleeding, no effective therapy to lessen the risk for lower GI bleeding in aspirin users. In fact, recent data has now shown that the use of PPIs increases the risk of lower GI damage significantly (Gastroenterology, 2011). Lower GI toxicity of aspirin is now known to be more insidious than upper GI damage, leading to higher mortality and longer hospital stays (Annals of Internal Medicine, 2010).
ATB-340 ADVANTAGE(S) ATB-340 delivers the cardiovascular disease prevention associated with aspirin but without the serious risk of gastrointestinal bleeding. Pre-clinical studies have demonstrated that ATB-340 caused negligible GI damage compared to low-dose aspirin.
STATUS Antibe is presently evaluating the clinical development strategy for ATB-340 and anticipates commencing pre-clinical toxicology studies in 2017.