Antibe Therapeutics is pursuing a major advance in the safe and non-addictive treatment of pain and inflammation. Our drugs are designed to prevent the widespread and serious gastrointestinal damage and bleeding caused by non-steroidal anti-inflammatory drugs (“NSAIDs”), today’s most widely used medicines for the relief of pain. The NSAID class of drugs includes prescription and over-the-counter (“OTC”) brands such as naproxen (Aleve), celecoxib (Celebrex), ibuprofen (Advil), and Aspirin.
Global NSAID sales exceed $12 billion annually, a massive market opportunity that could potentially be disrupted by Antibe’s H2S technology.
Now in Phase 2 human clinical trials, Antibe’s first drug targets mild-to-moderate pain and inflammation arising from a wide range of medical conditions. If the promising results of our pre-clinical studies are replicated in humans, Antibe will have surmounted the main barrier to the non-addictive control of pain and inflammation. Physicians and consumers will gain a radically safer alternative to today’s NSAIDs and to the multi-dimensional dangers of corticosteroids (used for inflammation) and opiates (used for pain).
Rooted in more than ten years of academic and proprietary research, Antibe’s patent-protected drug development technology enables the linking of an NSAID molecule to a hydrogen sulfide-releasing molecule. Notably, hydrogen sulfide (“H2S”) is endogenously produced and utilized throughout the body, serving as an anti-inflammatory agent and signaling molecule. Combined with an expanding scope of indications for NSAID use, the unique properties of hydrogen sulfide promise substantially improved medicines for pain and inflammation across the spectrum of human illness.